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UMI-77
CAS No. 518303-20-3
UMI-77( UMI-77, UMI77, UMI 77 )
Catalog No. M14810 CAS No. 518303-20-3
A potent and selective Mcl-1 inhibitor with Ki of 0.49 uM; displays >10 fold selectivity against Bcl-w, Bfl-1, Bcl-xL and Bcl-2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 79 | In Stock |
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| 2MG | 48 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 211 | In Stock |
|
| 50MG | 343 | In Stock |
|
| 100MG | 494 | In Stock |
|
| 200MG | 714 | In Stock |
|
| 500MG | 1070 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUMI-77
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective Mcl-1 inhibitor with Ki of 0.49 uM; displays >10 fold selectivity against Bcl-w, Bfl-1, Bcl-xL and Bcl-2.
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DescriptionA potent and selective Mcl-1 inhibitor with Ki of 0.49 uM; displays >10 fold selectivity against Bcl-w, Bfl-1, Bcl-xL and Bcl-2; inhibits cell growth and induces apoptosis in pancreatic cancer cells; blocks the heterodimerization of Mcl-1/Bax and Mcl-1/Bak in cells; inhibits tumor growth in BxPC-3 xenograft model.
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In Vitro——
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In Vivo——
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SynonymsUMI-77, UMI77, UMI 77
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PathwayAngiogenesis
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TargetBcl-2
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RecptorMcl-1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number518303-20-3
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Formula Weight468.3415
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Molecular FormulaC18H14BrNO5S2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 28 mg/mL
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SMILESC1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)Br
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Chemical NameAcetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Abulwerdi F, et al. Mol Cancer Ther. 2014 Mar;13(3):565-75.
2. Mohammad RM, et al. Semin Cancer Biol. 2015 Dec;35 Suppl:S78-103.
3. Korfi K, et al. Cell Death Dis. 2016 Apr 7;7:e2177.
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