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BI-3802
CAS No. 2166387-65-9
BI-3802( BI3802 | BI 3802 )
Catalog No. M13459 CAS No. 2166387-65-9
BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 377 | In Stock |
|
| 2MG | 169 | In Stock |
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| 5MG | 282 | In Stock |
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| 10MG | 432 | In Stock |
|
| 25MG | 692 | In Stock |
|
| 50MG | 918 | In Stock |
|
| 100MG | 1265 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBI-3802
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NoteResearch use only, not for human use.
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Brief DescriptionBI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.
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DescriptionBI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM; inhibits the BCL6/Co-repressor complex formation with IC50 of 43 nM in vitro, also is a potent and efficacious degrader of the BCL6 protein in many DLBCL cell lines (DC50=20 nM in SU-DHL-4 cells); BI-3802 is a valuable probe compound for testing hypotheses around BCL6 biology.
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In Vitro——
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In Vivo——
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SynonymsBI3802 | BI 3802
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number2166387-65-9
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Formula Weight484.985
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Molecular FormulaC24H29ClN6O3
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Purity>98% (HPLC)
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SolubilityDMSO : 5 mg/mL 10.31 mM; Methanol : 2 mg/mL 4.12 mM; H2O : < 0.1 mg/mL
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SMILESO=C(NC)COC1=CC2=C(N(C)C1=O)C=CC(NC3=NC(N4C[C@@H](C)C[C@@H](C)C4)=NC=C3Cl)=C2
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Chemical Name2-((6-((5-chloro-2-((3S,5R)-3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)oxy)-N-methylacetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kerres N, et al. Cell Rep. 2017 Sep 19;20(12):2860-2875.
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