DLK-IN-14( DLK inhibitor 14 | MAP3K12-IN-14 )

Catalog No. M12382 CAS No. 1620574-24-4

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Product Name

DLK-IN-14
Note

Research use only, not for human use.
Brief Description

A potent, selective, CNS penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of 3 nM.
Description

A potent, selective, CNS penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of 3 nM; displays no significant inhibitory activity against a panel of 220 kinases (<70% inhibition at 1 uM); reduces JNK phosphorylation (p-JNK) in HEK293 cells with IC50 of 0.195 uM, reduces p-MKK4 and p-JNK in models of chronic neurodegeneration.
In Vitro

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In Vivo

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Synonyms

DLK inhibitor 14 | MAP3K12-IN-14
Pathway

MAPK/ERK Signaling
Target

MEK
Recptor

MEK
Research Area

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Indication

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CAS Number

1620574-24-4
Formula Weight

423.44
Molecular Formula

C20H24F3N5O2
Purity

>98% (HPLC)
Solubility

DMSO : 62.5 mg/mL 147.60 mM
SMILES

CC(N1C([C@@H]2[C@]3([H])[C@@]2([H])CN(C4COC4)C3)=CC(C5=CN=C(N)C(OC(F)(F)F)=C5)=N1)C
Chemical Name

2-Pyridinamine, 5-[1-(1-methylethyl)-5-[(1α,5α,6α)-3-(3-oxetanyl)-3-azabicyclo[3.1.0]hex-6-yl]-1H-pyrazol-3-yl]-3-(trifluoromethoxy)-

1. Patel S, et al. J Med Chem. 2017 Oct 12;60(19):8083-8102.

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