TAOK inhibitor 63( —— )

Catalog No. M16176 CAS No. 850467-91-3

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Product Name

TAOK inhibitor 63
Note

Research use only, not for human use.
Brief Description

TAOK inhibitor 63 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 19 and 39 nM against TAOK1 (MAP3K16) and TAOK2 (MAP3K17), respectively.
Description

TAOK inhibitor 63 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 19 and 39 nM against TAOK1 (MAP3K16) and TAOK2 (MAP3K17), respectively; increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growth in centrosome-amplified SKBR3 or BT549 breast cancer cell models.
In Vitro

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In Vivo

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Synonyms

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Pathway

MAPK/ERK Signaling
Target

MEK
Recptor

MEK
Research Area

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Indication

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CAS Number

850467-91-3
Formula Weight

488.562
Molecular Formula

C26H24N4O4S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

N-{3-[(2-{[6-methoxy-1,3-benzothiazol-2-yl]amino}-2-oxoethyl)amino]-3-oxo-1-phenylpropyl}benzamide

1. Koo CY, et al. Mol Cancer Ther. 2017 Nov;16(11):2410-2421.

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