TAOK inhibitor 43( CP 43 | CP43 | CP-43 )

Catalog No. M16175 CAS No. 850467-66-2

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Product Name

TAOK inhibitor 43
Note

Research use only, not for human use.
Brief Description

TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively.
Description

TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively; increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growth in centrosome-amplified SKBR3 or BT549 breast cancer cell models.
In Vitro

TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells.
In Vivo

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Synonyms

CP 43 | CP43 | CP-43
Pathway

MAPK/ERK Signaling
Target

MEK
Recptor

MEK
Research Area

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Indication

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CAS Number

850467-66-2
Formula Weight

384.5
Molecular Formula

C25H24N2O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (162.56 mM)
SMILES

O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NCC(NC3CCCC4=C3C=CC=C4)=O
Chemical Name

N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide

1. Koo CY, et al. Mol Cancer Ther. 2017 Nov;16(11):2410-2421.

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