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GW284543
CAS No. 790186-68-4
GW284543( UNC10225170 )
Catalog No. M20902 CAS No. 790186-68-4
GW284543 is a selective inhibitor of MEK5 .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 72 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 101 | In Stock |
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| 25MG | 186 | In Stock |
|
| 50MG | 305 | In Stock |
|
| 100MG | 492 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGW284543
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NoteResearch use only, not for human use.
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Brief DescriptionGW284543 is a selective inhibitor of MEK5 .
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DescriptionGW284543 is a selective inhibitor of MEK5 .
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In VitroWestern Blot Analysis Cell Line:MIA PaCa-2 cells Concentration:10 and 20 μM Incubation Time:6 hours Result:Reduced phosphorylation of ERK5, and decreased endogenous MYC protein.
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In Vivo——
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SynonymsUNC10225170
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorMEK5
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Research Area——
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Indication——
Chemical Information
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CAS Number790186-68-4
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Formula Weight372.42
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Molecular FormulaC23H20N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (335.64 mM)
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SMILESCOc1cc2nccc(Nc3cccc(Oc4ccccc4)c3)c2cc1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Vaseva AV Blake DR Gilbert TSKet al.KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism[J].Cancer Cell. 2018 Nov 12;34(5):807-822.e7.
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