Tpl2-IN-34( Tpl2 inhibitor 34 | MAP3K8-IN-34 )

Catalog No. M16575 CAS No. 915363-56-3

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Product Name

Tpl2-IN-34
Note

Research use only, not for human use.
Brief Description

A potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM.
Description

A potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM; dispalys 6875-fold selectivity over EGFR. P38, Src, CAMKII, MK2, PKA, and PKC (IC50>10 uM); inhibits LPS-induced TNF-α production in whole blood with IC50 of 0.3 uM; shows good efficacy in inhibiting TNF-alpha production in a LPS-stimulated rat inflammation model; orally active.
In Vitro

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In Vivo

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Synonyms

Tpl2 inhibitor 34 | MAP3K8-IN-34
Pathway

MAPK/ERK Signaling
Target

MEK
Recptor

MEK
Research Area

Cancer
Indication

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CAS Number

915363-56-3
Formula Weight

539.4347
Molecular Formula

C26H25Cl2FN8
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CCN1CCC(CC1)N2C=C(N=N2)CNC3=CC4=C(C(=CN=C4C(=C3)Cl)C#N)NC5=CC(=C(C=C5)F)Cl
Chemical Name

3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-

1. Wu J, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8.

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