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Refametinib R enantiomer

CAS No. 923032-38-6

Refametinib R enantiomer( BAY 869766 R enantiomer | RDEA119 R enantiomer | RDEA-119 R enantiomer | BAY 86-9766 R enantiomer )

Catalog No. M16610 CAS No. 923032-38-6

The R enantiomer of Refametinib, a potent, non–ATP-competitive, highly selective, allosteric inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Refametinib R enantiomer
  • Note
    Research use only, not for human use.
  • Brief Description
    The R enantiomer of Refametinib, a potent, non–ATP-competitive, highly selective, allosteric inhibitor.
  • Description
    The R enantiomer of Refametinib, a potent, non–ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.
  • In Vitro
    Refametinib R enantiomer is the R enantiomer of Refametinib . Refametinib R enantiomer is an inhibitor of MEK and is useful in treatment of cancer and other hyperproliferative diseases.
  • In Vivo
    ——
  • Synonyms
    BAY 869766 R enantiomer | RDEA119 R enantiomer | RDEA-119 R enantiomer | BAY 86-9766 R enantiomer
  • Pathway
    MAPK/ERK Signaling
  • Target
    MEK
  • Recptor
    MEK
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    923032-38-6
  • Formula Weight
    572.3372
  • Molecular Formula
    C19H20F3IN2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F
  • Chemical Name
    Cyclopropanesulfonamide, N-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2R)-2,3-dihydroxypropyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Iverson C, et al. Cancer Res. 2009 Sep 1;69(17):6839-47. 2. Chang Q, et al. BMC Cancer. 2010 Sep 28;10:515. 3. Schmieder R, et al. Neoplasia. 2013 Oct;15(10):1161-71.
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