BRD0209( BRD 0209 )

Catalog No. M12287 CAS No. 1597439-87-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BRD0209
Note

Research use only, not for human use.
Brief Description

BRD0209 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 19 nM/5 nM for GSK3α/GSK3β respectively.
Description

BRD0209 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 19 nM/5 nM for GSK3α/GSK3β respectively; displays remarkable selectivity versus the kinome; causes a dramatic decrease in autophosphorylation at Tyr279 (pGSK3α) and Tyr216 (pGSK3β) with longer exposure (24h).
In Vitro

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In Vivo

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Synonyms

BRD 0209
Pathway

PI3K/Akt/mTOR signaling
Target

GSK-3
Recptor

GSK-3
Research Area

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Indication

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CAS Number

1597439-87-6
Formula Weight

347.462
Molecular Formula

C22H25N3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (179.88 mM)
SMILES

O=C1C2=C(NC3=NNC(C4CC4)=C3[C@]2(C)C5=CC=CC=C5)CC(C)(C)C1
Chemical Name

(S)-3-Cyclopropyl-4,7,7-trimethyl-4-phenyl-2,4,6,7,8,9-hexahydro-pyrazolo[3,4-b]quinolin-5-one

1. Wagner FF, et al. ACS Chem Biol. 2016 Jul 15;11(7):1952-63.

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