GSK3β-IN-1a( —— )

Catalog No. M10492 CAS No. 1139875-74-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

GSK3β-IN-1a
Note

Research use only, not for human use.
Brief Description

GSK3β-IN-1a is a relatively selective and potent GSK-3β inhibitor with IC50 of 64 nM.
Description

GSK3β-IN-1a is a relatively selective and potent GSK-3β inhibitor with IC50 of 64 nM; induces replication of growth-arrested R7T1 β cells in a dose-dependent manner with EC50 of 1.1 uM, likely mediates β-cell proliferation through the Wnt signaling pathway.
In Vitro

——
In Vivo

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Synonyms

——
Pathway

PI3K/Akt/mTOR signaling
Target

GSK-3
Recptor

GSK-3
Research Area

——
Indication

——

CAS Number

1139875-74-3
Formula Weight

413.924
Molecular Formula

C20H20ClN5OS
Purity

>98% (HPLC)
Solubility

——
SMILES

CN1CCN(CC1)C(=O)C2=C(C=C(C=C2)NC3=NC=CC(=N3)C4=CC=CS4)Cl
Chemical Name

(2-chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone

1. Wang W, et al. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32.

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