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GSK3β-IN-1a

CAS No. 1139875-74-3

GSK3β-IN-1a( —— )

Catalog No. M10492 CAS No. 1139875-74-3

GSK3β-IN-1a is a relatively selective and potent GSK-3β inhibitor with IC50 of 64 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GSK3β-IN-1a
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK3β-IN-1a is a relatively selective and potent GSK-3β inhibitor with IC50 of 64 nM.
  • Description
    GSK3β-IN-1a is a relatively selective and potent GSK-3β inhibitor with IC50 of 64 nM; induces replication of growth-arrested R7T1 β cells in a dose-dependent manner with EC50 of 1.1 uM, likely mediates β-cell proliferation through the Wnt signaling pathway.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    GSK-3
  • Recptor
    GSK-3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1139875-74-3
  • Formula Weight
    413.924
  • Molecular Formula
    C20H20ClN5OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN1CCN(CC1)C(=O)C2=C(C=C(C=C2)NC3=NC=CC(=N3)C4=CC=CS4)Cl
  • Chemical Name
    (2-chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang W, et al. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32.
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