A 1070722

Research use only, not for human use.

A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α(Ki = 0.6 nM) and GSK-3β(Ki = 0.6 nM).

A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α(Ki = 0.6 nM) and GSK-3β(Ki = 0.6 nM). It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain.(In Vivo):PET imaging experiments in anesthetized vervet/African green monkey exhibited that A 1070722 penetrated the blood-brain barrier (BBB) and accumulated in brain regions, with highest radioactivity binding in frontal cortex followed by parietal cortex and anterior cingulate, and with the lowest bindings found in caudate, putamen, and thalamus, similarly to the known distribution of GSK-3 in human brain.

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PI3K/Akt/mTOR signaling

GSK-3

Thrombin

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1384424-80-9

362.312

C17H13F3N4O2

>98% (HPLC)

In Vitro:?DMSO : 83.33 mg/mL (230.00 mM)

COc1ccc2c(NC(=O)Nc3cccc(n3)C(F)(F)F)ccnc2c1

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(-20℃)

With Ice Pack

≥ 2 years