NLG919( GDC-0919 )

Catalog No. M11684 CAS No. 1402836-58-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NLG919
Note

Research use only, not for human use.
Brief Description

NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays. Phase 1.
Description

NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays. Phase 1.(In Vitro):IDO-IN-7 (NLG-919 analogue) is a potent IDO1 inhibitor (IC50=38 nM). The binding mode of IDO-IN-7 to IDO1 is experimentally available and shows a direct coordinative interaction to the sixth coordination site of ferric heme. IDO-IN-7 has been used as reference compound in other studies to validate high-throughput screening assay for IDO1 inhibition and develop immunostimulatory nanomicellar carrier.
In Vitro

IDO-IN-7 (NLG-919 analogue) is a potent IDO1 inhibitor (IC50=38 nM). The binding mode of IDO-IN-7 to IDO1 is experimentally available and shows a direct coordinative interaction to the sixth coordination site of ferric heme. IDO-IN-7 has been used as reference compound in other studies to validate high-throughput screening assay for IDO1 inhibition and develop immunostimulatory nanomicellar carrier.
In Vivo

——
Synonyms

GDC-0919
Pathway

Metabolic Enzyme/Protease
Target

IDO
Recptor

IDO
Research Area

Cancer
Indication

——

CAS Number

1402836-58-1
Formula Weight

282.38
Molecular Formula

C18H22N2O
Purity

>98% (HPLC)
Solubility

Ethanol: 56 mg/mL warmed (198.31 mM); DMSO: 15 mg/mL warmed (53.11 mM)
SMILES

OC(C1CCCCC1)CC(C2=C3C=CC=C2)N4C3=CN=C4
Chemical Name

1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol

1.AACR Meeting, Poster 491, 2013.

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