JNJ-42165279( JNJ42165279 | JNJ 42165279 )

Catalog No. M11398 CAS No. 1346528-50-4

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Product Name

JNJ-42165279
Note

Research use only, not for human use.
Brief Description

JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH.
Description

JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH; no inhibition on CYPs and hERG at 10 uM; blocks FAAH in the brain and periphery of rats , causes an elevation of the concentrations of AEA, OEA, and PEA; demonstrates activity in the spinal nerve ligation (SNL) model of neuropathic pain; exhibited excellent ADME and pharmacodynamic properties.Anxiety Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

JNJ42165279 | JNJ 42165279
Pathway

Metabolic Enzyme/Protease
Target

FAAH
Recptor

hFAAH|rFAAH
Research Area

Neurological Disease
Indication

Anxiety

CAS Number

1346528-50-4
Formula Weight

410.8024
Molecular Formula

C18H17ClF2N4O3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

C1CN(CCN1CC2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4=C(C=CN=C4)Cl
Chemical Name

1-Piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-

1. Keith JM, et al. ACS Med Chem Lett. 2015 Nov 2;6(12):1204-8.

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