JNJ-42165279

CAS No. 1346528-50-4

JNJ-42165279( JNJ42165279 | JNJ 42165279 )

Catalog No. M11398 CAS No. 1346528-50-4

JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 66 In Stock
2MG 36 In Stock
5MG 56 In Stock
10MG 84 In Stock
25MG 164 In Stock
50MG 241 In Stock
100MG 355 In Stock
200MG 501 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    JNJ-42165279
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH.
  • Description
    JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH; no inhibition on CYPs and hERG at 10 uM; blocks FAAH in the brain and periphery of rats , causes an elevation of the concentrations of AEA, OEA, and PEA; demonstrates activity in the spinal nerve ligation (SNL) model of neuropathic pain; exhibited excellent ADME and pharmacodynamic properties.Anxiety Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    JNJ42165279 | JNJ 42165279
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    FAAH
  • Recptor
    hFAAH|rFAAH
  • Research Area
    Neurological Disease
  • Indication
    Anxiety

Chemical Information

  • CAS Number
    1346528-50-4
  • Formula Weight
    410.8024
  • Molecular Formula
    C18H17ClF2N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1CN(CCN1CC2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4=C(C=CN=C4)Cl
  • Chemical Name
    1-Piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Keith JM, et al. ACS Med Chem Lett. 2015 Nov 2;6(12):1204-8.
molnova catalog
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