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JNJ-42165279
CAS No. 1346528-50-4
JNJ-42165279( JNJ42165279 | JNJ 42165279 )
Catalog No. M11398 CAS No. 1346528-50-4
JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 66 | In Stock |
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| 2MG | 36 | In Stock |
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| 5MG | 56 | In Stock |
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| 10MG | 84 | In Stock |
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| 25MG | 164 | In Stock |
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| 50MG | 241 | In Stock |
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| 100MG | 355 | In Stock |
|
| 200MG | 501 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJNJ-42165279
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NoteResearch use only, not for human use.
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Brief DescriptionJNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH.
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DescriptionJNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH; no inhibition on CYPs and hERG at 10 uM; blocks FAAH in the brain and periphery of rats , causes an elevation of the concentrations of AEA, OEA, and PEA; demonstrates activity in the spinal nerve ligation (SNL) model of neuropathic pain; exhibited excellent ADME and pharmacodynamic properties.Anxiety Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsJNJ42165279 | JNJ 42165279
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PathwayMetabolic Enzyme/Protease
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TargetFAAH
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RecptorhFAAH|rFAAH
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Research AreaNeurological Disease
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IndicationAnxiety
Chemical Information
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CAS Number1346528-50-4
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Formula Weight410.8024
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Molecular FormulaC18H17ClF2N4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1CN(CCN1CC2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4=C(C=CN=C4)Cl
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Chemical Name1-Piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Keith JM, et al. ACS Med Chem Lett. 2015 Nov 2;6(12):1204-8.
molnova catalog
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