AA26-9

Research use only, not for human use.

AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.

AA26-9 is a potent and broad-spectrum serine hydrolase inhibitor. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases, thioesterases, and uncharacterized enzymes.

AA26-9 is synthesized based on a piperazine scaffold shown previously to inhibit serine hydrolases in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptidases (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme’s serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells.

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AA 26-9 | AA-26-9 | AA26-9 | AA 269

Metabolic Enzyme/Protease

FAAH

serine hydrolase

Others-Field

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1312782-34-5

166.18

C7H11N4O

>98% (HPLC)

DMSO : 100 mg/mL. 601.76 mM;

O=C(N1CCCC1)N2N=NC=C2

Pyrrolidin-1-yl(triazol-1-yl)methanone

(-20℃)

With Ice Pack

≥ 2 years