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(-) BI97D6

CAS No. 1256724-10-3

(-) BI97D6( BI97D6 )

Catalog No. M11053 CAS No. 1256724-10-3

(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    (-) BI97D6
  • Note
    Research use only, not for human use.
  • Brief Description
    (-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively.
  • Description
    (-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively; effectively inhibits cell growth in the PC-3 human prostate cancer and H23 human lung cancer cell lines with EC50 of 0.22 and 0.14 uM, respectively; effectively induces apoptosis in the BP3 human lymphoma cell line; displays in vivo efficacy in a prostate cancer xenograft model in mice; also overcomes ABT-737 resistance in AML, kills AML leukemia stem/progenitor cells while largely sparing normal hematopoietic stem/progenitor cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BI97D6
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1256724-10-3
  • Formula Weight
    586.596
  • Molecular Formula
    C36H26O8
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    5,5'-dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',4,4'-tetraone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wei J, et al. Front Oncol. 2011 Sep 30;1:28. 2. Pan R, et al. Blood. 2015 Jul 16;126(3):363-72. 3. Wei J, et al. J Med Chem. 2009 Jul 23;52(14):4511-23.
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