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Chelerythrine chloride
CAS No. 3895-92-9
Chelerythrine chloride( Broussonpapyrine chloride | NSC 646662 )
Catalog No. M14342 CAS No. 3895-92-9
Chelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 57 | In Stock |
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| 10MG | 81 | In Stock |
|
| 25MG | 162 | In Stock |
|
| 50MG | 284 | In Stock |
|
| 100MG | 518 | In Stock |
|
| 500MG | 1134 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameChelerythrine chloride
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NoteResearch use only, not for human use.
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Brief DescriptionChelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK.
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DescriptionChelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK, also inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 uM and displaces Bax from Bcl-XL; inhibits LPS-induced TNF-α level and NO production in LPS-induced murine peritoneal macrophages through selective inhibition of p38 MAPK and ERK1/2 activation; triggers apoptosis via direct action on mitochondria.
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In Vitro——
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In Vivo——
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SynonymsBroussonpapyrine chloride | NSC 646662
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PathwayAngiogenesis
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TargetBcl-2
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RecptorPKC
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number3895-92-9
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Formula Weight383.8249
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Molecular FormulaC21H18ClNO4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 3.9 mg/mL
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SMILESC[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
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Chemical Name1,2-Dimethoxy-12-methyl[1,3]benzodi oxolo[5,6-c]phenanthridinium chloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chan SL, et al. J Biol Chem. 2003 Jun 6;278(23):20453-6.
2. Li W, et al. Inflammation. 2012 Dec;35(6):1814-24.
3. Wan KF, et al. J Biol Chem. 2008 Mar 28;283(13):8423-33.
4. Zhang YH, et al. J Mol Biol. 2006 Dec 1;364(3):536-49.
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