Cart
sales@molnova.com
MI-223
CAS No. 907166-59-0
MI-223( NSC 320223 )
Catalog No. M16518 CAS No. 907166-59-0
MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMI-223
-
NoteResearch use only, not for human use.
-
Brief DescriptionMI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM.
-
DescriptionMI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents; not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress; exhibits a strong synergy against lung cancer in vivo combined with Olaparib.
-
In Vitro——
-
In Vivo——
-
SynonymsNSC 320223
-
PathwayAngiogenesis
-
TargetBcl-2
-
RecptorBcl-2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number907166-59-0
-
Formula Weight419.865
-
Molecular FormulaC23H18ClN3O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1N(/N=C/C2=CC=CC(OCC)=C2O)C(C3=CC=CC=C3Cl)=NC4=C1C=CC=C4
-
Chemical Name2-(2-chlorophenyl)-3-[[(Z)-(5-ethoxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]quinazolin-4-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516.
molnova catalog
related products
-
BCL6 inhibitor 7
A potent BCL6 protein-protein interaction inhibitor with Kd of 78 nM; exhibits an efficacy in cell-free and cellular PPI assays.
-
AZD 4320
AZD4320 is a BH3 mimetic and dual Bcl-2/Bcl-XL inhibitor with IC50 of <1 nM.
-
BTSA1
BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.
