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S44563
CAS No. 1044900-59-5
S44563( S 44563 )
Catalog No. M10224 CAS No. 1044900-59-5
S44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameS44563
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NoteResearch use only, not for human use.
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Brief DescriptionS44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively.
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DescriptionS44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively; induces in vitro apoptosis of melanoma xenograft-derived cell lines MP41, MM26, and MM66 with IC50 of 4, 7 and 6 uM; increases the efficacy of fotemustine in either concomitant or sequential combinations or indeed subsequent to fotemustine in vivo, also enhance radiosensitivity of SCLC cells in vitro and in vivo.
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In Vitro——
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In Vivo——
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SynonymsS 44563
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research Area——
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Indication——
Chemical Information
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CAS Number1044900-59-5
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Formula Weight839.467
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Molecular FormulaC44H47ClN6O5S2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(4aR)-3-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ashkenazi A, et al. Nat Rev Drug Discov. 2017 Apr;16(4):273-284.
2. Némati F, et al. PLoS One. 2014 Jan 13;9(1):e80836.
3. Loriot Y, et al. Cell Death Dis. 2014 Sep 18;5:e1423.
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