MX69( MX 69 | MX-69 )

Catalog No. M10044 CAS No. 1005264-47-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MX69
Note

Research use only, not for human use.
Brief Description

A novel specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM.
Description

A novel specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM; induces ubiquitination of endogenous MDM2, results in activation of p53 and inhibition of XIAP, and induces cell apoptosis and death in cancer cells; shows significant apoptotic and anti-proliferative effects on MDM2-expressing cancer cells both in vitro and in vivo, with minimal inhibitory effect on normal human hematopoiesis.
In Vitro

MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 down regulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro.
In Vivo

MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo.
Synonyms

MX 69 | MX-69
Pathway

Apoptosis
Target

MDM2-p53
Recptor

Mdm2
Research Area

Cancer
Indication

——

CAS Number

1005264-47-0
Formula Weight

474.57134
Molecular Formula

C27H26N2O4S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 30 mg/mL
SMILES

O=S(C1=CC2=C(NC(C3=CC=C(C(O)=O)C=C3)C4C2C=CC4)C=C1)(NC5=C(C)C(C)=CC=C5)=O
Chemical Name

4-{8-[(3,4-Dimethylphenyl)sulfamoyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl}benzoic acid

1. Gu L, et al. Cancer Cell. 2016 Oct 10;30(4):623-636.

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