MMRi64( MMRi64 )

Catalog No. M14460 CAS No. 430458-66-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MMRi64
Note

Research use only, not for human use.
Brief Description

MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells.
Description

MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells; potently induces downregulation of Mdm2 and MdmX in leukemia cells, only induces the expression of pro-apoptotic gene PUMA (p53 upregulated modulator of apoptosis) with minimal induction of growth-arresting gene p21; selectively induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells; synergistically induces p53 and apoptosis in combination with Nutlin3a.
In Vitro

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In Vivo

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Synonyms

MMRi64
Pathway

Apoptosis
Target

MDM2-p53
Recptor

MDM2-p53
Research Area

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Indication

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CAS Number

430458-66-5
Formula Weight

410.298
Molecular Formula

C22H17Cl2N3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (243.72 mM)
SMILES

OC1=C2N=CC=CC2=CC=C1C(C3=CC=CC(Cl)=C3Cl)NC4=NC=CC(C)=C4
Chemical Name

7-[(2,3-Dichlorophenyl)[(4-methyl-2-pyridinyl)amino]methyl]-8-quinolinol

1. Wu W, et al. Cell Death Dis. 2015 Dec 31;6:e2035.

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