RO-8994( RO8994 )

Catalog No. M11239 CAS No. 1309684-94-3

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Product Name

RO-8994
Note

Research use only, not for human use.
Brief Description

A highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM.
Description

A highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM; shows marked improvement in both in vitro and in vivo pharmacological properties.
In Vitro

——
In Vivo

——
Synonyms

RO8994
Pathway

Apoptosis
Target

MDM2-p53
Recptor

Mdm2|P53
Research Area

Cancer
Indication

——

CAS Number

1309684-94-3
Formula Weight

613.5067
Molecular Formula

C31H31Cl2FN4O4
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 45 mg/mL
SMILES

CC(C)(C)CC1C2(C(C(N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O
Chemical Name

Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-

1. Zhang Z, et al. Bioorg Med Chem. 2014 Aug 1;22(15):4001-9. 2. Yu B, et al. Anticancer Agents Med Chem. 2016;16(10):1315-24.

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