Cart
sales@molnova.com
MS7972
CAS No. 352553-42-5
MS7972( MS 7972 )
Catalog No. M14203 CAS No. 352553-42-5
MS7972 is a small molecules that blocks p53 and CREB binding protein (CBP) association.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 119 | In Stock |
|
| 5MG | 107 | In Stock |
|
| 10MG | 183 | In Stock |
|
| 25MG | 312 | In Stock |
|
| 50MG | 440 | In Stock |
|
| 100MG | 603 | In Stock |
|
| 200MG | 812 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMS7972
-
NoteResearch use only, not for human use.
-
Brief DescriptionMS7972 is a small molecules that blocks p53 and CREB binding protein (CBP) association.
-
DescriptionMS7972 is a small molecules that blocks p53 and CREB binding protein (CBP) association; completely blocks CBP BRD/p53-AcK382 interactions at 50 uM, results in loss of p53 phosphorylation at Ser15 as well as acetylation at Lys382; causes a dramatic decrease of the doxorubicin-induced p53 increase in U2OS cells.
-
In VitroAddition of MS7972 to the CBP BRD results in emission at 445 nm and quenching of the CBP BRD due to resonance energy transfer.
-
In Vivo——
-
SynonymsMS 7972
-
PathwayApoptosis
-
TargetMDM2-p53
-
RecptorMDM2-p53
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number352553-42-5
-
Formula Weight227.263
-
Molecular FormulaC14H13NO2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (440.02 mM)
-
SMILESO=C1C(N(C(C)=O)C2=C3C=CC=C2)=C3CCC1
-
Chemical Name9-Acetyl-3,4-dihydro-2H-carbazol-1-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Sachchidanand, et al. Chem Biol. 2006 Jan;13(1):81-90.
molnova catalog
related products
-
HDM-201
HDM-201 (NVP-HDM 201, Siremadlin)?is a highly potent p53-MDM2 interaction inhibitor with biochemical IC50 of 0.13 nM, cellular IC50 of 90 nM.
-
SM13
SM13 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
-
RITA
RITA(NSC 652287) induced both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks. RITA, a drug that, like nutlin-3, can disrupt the p53/Mdm2 interaction.
