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LY2979165
CAS No. 1311385-32-6
LY2979165( mGlu2 agonist )
Catalog No. M26747 CAS No. 1311385-32-6
LY2979165 is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 113 | In Stock |
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| 5MG | 178 | In Stock |
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| 10MG | 237 | In Stock |
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| 25MG | 420 | In Stock |
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| 50MG | 617 | In Stock |
|
| 100MG | 878 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLY2979165
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NoteResearch use only, not for human use.
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Brief DescriptionLY2979165 is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.
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DescriptionLY2979165 is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.(In Vivo):LY2979165 reduces BOLD signal and increases plasma levels of 2812223 in vivo.
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In Vitro——
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In VivoLY2979165 attenuated the ketamine-evoked BOLD phMRI signal in vivo.
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SynonymsmGlu2 agonist
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PathwayNeuroscience
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TargetGluR
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RecptorNK1| NK3
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Research Area——
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Indication——
Chemical Information
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CAS Number1311385-32-6
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Formula Weight390.42
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Molecular FormulaC13H22N6O6S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : ≥ 50 mg/mL (128.07 mM)D)
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SMILESN.O.C[C@H](N)C(=O)N[C@]1(C[C@@H](Sc2ncn[nH]2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Basimglurant
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM).
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LY341495
LY341495 is a potent metabotropic glutamate receptor antagonist that exhibits high activity against a wide range of glutamate receptor subtypes and can be used for the study of neurological disorders.
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DNQX
DNQX is a competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors respectively).
