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LB-100
CAS No. 1632032-53-1
LB-100( LB100 )
Catalog No. M12454 CAS No. 1632032-53-1
LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor; exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 64 | In Stock |
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| 5MG | 97 | In Stock |
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| 10MG | 178 | In Stock |
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| 25MG | 284 | In Stock |
|
| 50MG | 422 | In Stock |
|
| 100MG | 618 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLB-100
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NoteResearch use only, not for human use.
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Brief DescriptionLB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor; exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM.
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DescriptionLB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor; exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM; synergistically enhances the activity of doxorubicin and induces expression of HIF-1α and VEGF; significantly enhances tumor growth inhibition by cisplatin in vivo.Brain Cancer Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsLB100
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PathwayMetabolic Enzyme/Protease
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TargetProtein Phosphatase/PTP
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RecptorPP2A
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Research AreaCancer
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IndicationBrain Cancer
Chemical Information
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CAS Number1632032-53-1
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Formula Weight268.3089
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Molecular FormulaC13H20N2O4
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Purity>98% (HPLC)
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SolubilityH2O: ≥ 48 mg/mL; DMSO: < 2.9 mg/mL
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SMILESO=C(C1C(O2)CCC2C1C(N3CCN(C)CC3)=O)O
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Chemical Name7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid, 3-[(4-methyl-1-piperazinyl)carbonyl]-, (1R,4S)-rel-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bai XL, et al. Mol Cancer Ther. 2014 Aug;13(8):2062-72.
2. Chang KE, et al. Mol Cancer Ther. 2015 Jan;14(1):90-100.
3. Gordon IK, et al. Mol Cancer Ther. 2015 Jul;14(7):1540-7.
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