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Home - Products - Metabolic Enzyme/Protease - Transferase - JNJ-DGAT2-A

JNJ-DGAT2-A

CAS No. 1962931-71-0

JNJ-DGAT2-A( —— )

Catalog No. M34299 CAS No. 1962931-71-0

JNJ-DGAT2-A, a specific inhibitor of DGAT2(IC50 = 0.14 μM), can be used in studies about the synthesis of triglycerides.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    JNJ-DGAT2-A
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ-DGAT2-A, a specific inhibitor of DGAT2(IC50 = 0.14 μM), can be used in studies about the synthesis of triglycerides.
  • Description
    JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis.
  • In Vitro
    JNJ-DGAT2-A (5 μM) inhibits about 99% of recombinant DGAT2 enzymatic activity.JNJ-DGAT2-A (5 μM) inhibits the DGAT activity in HepG2 cell lysates.JNJ-DGAT2-A (0.3125, 0.625, 1.25, 2.5, 5, 10, and 20 μM; 60 min prior to isotope-labeled and additional 2 h after isotope-labeled) dose-dependently inhibits the generation of TG (52:2), TG (54:3), and TG (50:2) using 13C3-D5-glycerol as a substrate in HepG2 cells with IC50 values of 0.85 μM, 0.99 μM, and 0.66 μM, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Transferase
  • Recptor
    Transferase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1962931-71-0
  • Formula Weight
    523.38
  • Molecular Formula
    C24H16BrFN4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 3.33 mg/mL (6.36 mM; Ultrasonic (<60°C)
  • SMILES
    Fc1cc(\C=C2/SC(NCCc3ccccn3)=NC2=O)ccc1Oc1ccc(cc1Br)C#N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Qi J, et al. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. J Lipid Res. 2012 Jun;53(6):1106-16.?
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