IOX4

Research use only, not for human use.

IOX4 (PHD2 inhibitor IOX4) is a potent, selective inhibitor of prolyl hydroxylase domain enzyme PHD2 with IC50 of 1.6 nM.

IOX4 (PHD2 inhibitor IOX4) is a potent, selective inhibitor of prolyl hydroxylase domain enzyme PHD2 with IC50 of 1.6 nM, displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases; inhibits prolyl hydroxylation and increases HIF-1α levels in cells (IC50=5.6 to 11.7 μM), also induces HIF-1α and HIF-2α expression in mice.

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PHD2 inhibitor IOX4

Angiogenesis

HIF/HIF Prolyl-hydroxylase

HIF/HIF Prolyl-hydroxylase

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1154097-71-8

328.3

C15H16N6O3

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (152.29 mM)

CC(C)(C)OC(C1=CN=C(N2NC=C(N3C=CN=N3)C2=O)C=C1)=O

1,1-dimethylethyl ester 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-3-pyridinecarboxylic acid

(-20℃)

With Ice Pack

≥ 2 years