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Home - Products - Cell Cycle/DNA Damage - DNA Repair Protein - IACS-4759

IACS-4759

CAS No. 1884209-99-7

IACS-4759( IACS4759 )

Catalog No. M12940 CAS No. 1884209-99-7

IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IACS-4759
  • Note
    Research use only, not for human use.
  • Brief Description
    IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.
  • Description
    IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    IACS4759
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Repair Protein
  • Recptor
    DNA Repair Protein
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1884209-99-7
  • Formula Weight
    211.265
  • Molecular Formula
    C10H17N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    3-((2-amino-5-methylpyrimidin-4-yl)oxy)-2,2-dimethylpropan-1-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7.
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