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IACS-4619
CAS No. 1884209-98-6
IACS-4619( IACS4619 )
Catalog No. M12939 CAS No. 1884209-98-6
IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameIACS-4619
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NoteResearch use only, not for human use.
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Brief DescriptionIACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM.
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DescriptionIACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.
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In Vitro——
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In Vivo——
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SynonymsIACS4619
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PathwayCell Cycle/DNA Damage
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TargetDNA Repair Protein
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RecptorDNA Repair Protein
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Research Area——
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Indication——
Chemical Information
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CAS Number1884209-98-6
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Formula Weight195.266
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Molecular FormulaC10H17N3O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name5-methyl-4-(neopentyloxy)pyrimidin-2-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7.
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