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HIF-1 inhibitor-4

CAS No. 333357-56-5

HIF-1 inhibitor-4( —— )

Catalog No. M35970 CAS No. 333357-56-5

HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HIF-1 inhibitor-4
  • Note
    Research use only, not for human use.
  • Brief Description
    HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level.
  • Description
    HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    HIF/HIF Prolyl-hydroxylase
  • Recptor
    HIF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    333357-56-5
  • Formula Weight
    422.26
  • Molecular Formula
    C18H19IN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (59.21 mM; Ultrasonic (<60°C)
  • SMILES
    IC1=CC=C(NC(=O)C2=CC=C(CN3CCOCC3)C=C2)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5513-29. ?
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