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DGAT

TAGs, also termed blood fats, are found in most eukaryotic cells, where they are a mechanism for storing unused calories. They also play an important role in maintaining normal physiology. In eukaryotic cells, TAGs are resynthesized through a reaction catalyzed by diacylglycerol acyltransferase after dietary TAG has been digested and absorbed from by the small intestine as fatty acids and monoacylglycerol. The final and only committed step in the synthesis of TAG is common to both pathways and is catalyzed by acyl-CoA:diacylglycerol acyltransferase (DGAT). This enzyme family is composed of DGAT-1 and DGAT-2, which are encoded by two distinct genes. DGATs have been important molecular tools for examining the relationship between obesity and TAG synthesis. The inhibition of TAG synthesis has been suggested as a method of disrupting lipid absorption in the small intestine, thereby restoring the energy balance through a decrease in energy input; therefore, the inhibition of TAG synthesis in both adipose and non-adipose tissues may be beneficial and a potential therapeutic strategy leading to protection against obesity.

References

1.Naik R,et al. ChemMedChem. 2014 Nov;9(11):2410-24.

Metabolic Enzyme/Protease

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