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TAT-Gap19
TAT-Gap19
Catalog No. M30790
Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19. Active in vivo. Brain penetrant.
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Biological Information
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Product NameTAT-Gap19
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Brief Description
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Description
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Storage
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NoteResearch use only, not for human use.
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Reference1. Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 8 1 PMID:
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Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19. Active in vivo. Brain penetrant.
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Gap19
Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.
