Gap19

Research use only, not for human use.

Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.

Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.(In Vitro):Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo. (In Vivo):Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth.

Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo.

Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth. Animal Model:C57/BL6 mice Dosage:25 mg/kg Administration:IV; 10 min before ligation Result:Significantly reduced the infarct size by approximately one-fifth.

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Cytoskeleton/Cell Adhesion Molecules

Gap Junction Protein

Cx43 Hemichannel

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1507930-57-5

1161.44

C55H96N14O13

>98% (HPLC)

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Sequence:{Lys}{Gln}{Ile}{Glu}{Ile}{Lys}{Lys}{Phe}{Lys}

(-20℃)

With Ice Pack

≥ 2 years