Carbenoxolone disodium( Biogastrone | Bioral | Carbenoxolone sodium | Duogastrone | Pyrogastrone | Sanodin )

Catalog No. M15836 CAS No. 7421-40-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Carbenoxolone disodium
Note

Research use only, not for human use.
Brief Description

An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity.
Description

An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity.
In Vitro

Cell Viability Assay Cell Line:HaCaT cells Concentration:6 μM, 12 μM, 30 μM, 60 μM, 150 μM Incubation Time:Pre-treatment 1 hour Result:Had no toxicity until 48 hours at high dose in virus-infected cells. Western Blot Analysis Cell Line:HaCaT cells Concentration:30 μM Incubation Time:Pre-treatment 1 hour Result:Presented an obvious upregulation of A27.
In Vivo

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Synonyms

Biogastrone | Bioral | Carbenoxolone sodium | Duogastrone | Pyrogastrone | Sanodin
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Gap Junction Protein
Recptor

Gap Junction Protein
Research Area

Inflammation/Immunology
Indication

Psoriasis

CAS Number

7421-40-1
Formula Weight

614.72
Molecular Formula

C34H48Na2O7
Purity

>98% (HPLC)
Solubility

Water: 100 mM
SMILES

CC(C)([C@](CC[C@@]([C@@]1(CC[C@]2(CC[C@](C([O-])=O)(C[C@]2(C1=C3)[H])C)C)C)4C)5[H])[C@@H](OC(CCC([O-])=O)=O)CC[C@]5(C)[C@@]4([H])C3=O.[Na+].[Na+]
Chemical Name

sodium (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-((3-carboxylatopropanoyl)oxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate

1.Hausmann W, Tárnoky AL. Br J Pharmacol ChemOthers. 1966 Feb;26(2):412-20.

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