AMG-47a is a potent inhibitor of Lck and T cell proliferation.?AMG-47a could promote the degradation of the KRAS oncoprotein.?AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.

1-Naphthyl PP1 is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)

A-770041 is selective and orally active Src-family Lck inhibitor, and the other Src family kinase involved in T-cell signaling.