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AMG-47a
CAS No. 882663-88-9
AMG-47a( —— )
Catalog No. M20616 CAS No. 882663-88-9
AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 80 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 236 | In Stock |
|
| 50MG | 350 | In Stock |
|
| 100MG | 516 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAMG-47a
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NoteResearch use only, not for human use.
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Brief DescriptionAMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
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DescriptionAMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayTyrosine Kinase
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TargetSrc
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RecptorLck
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Research Area——
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Indication——
Chemical Information
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CAS Number882663-88-9
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Formula Weight535.56
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Molecular FormulaC29H28F3N5O2
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Purity>98% (HPLC)
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SolubilityDMSO:34 mg/mL (63.48 mM)
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SMILESCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1
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Chemical Name4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Carver J Dexheimer T S Hsu D et al. A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein[J]. Plos One 2014 9(8):e103836.
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AMG-47a
AMG-47a is a potent inhibitor of Lck and T cell proliferation.?AMG-47a could promote the degradation of the KRAS oncoprotein.?AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
