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AMG-47a

CAS No. 882663-88-9

AMG-47a( —— )

Catalog No. M20616 CAS No. 882663-88-9

AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 92 In Stock
5MG 85 In Stock
10MG 147 In Stock
25MG 249 In Stock
50MG 362 In Stock
100MG 533 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    AMG-47a
  • Note
    Research use only, not for human use.
  • Brief Description
    AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
  • Description
    AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Tyrosine Kinase
  • Target
    Src
  • Recptor
    Lck
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    882663-88-9
  • Formula Weight
    535.56
  • Molecular Formula
    C29H28F3N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:34 mg/mL (63.48 mM)
  • SMILES
    Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1
  • Chemical Name
    4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Carver J Dexheimer T S Hsu D et al. A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein[J]. Plos One 2014 9(8):e103836.
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