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Home - Products - Metabolic Enzyme/Protease - Phosphatase - Vutiglabridin

Vutiglabridin

CAS No. 1800188-47-9

Vutiglabridin( —— )

Catalog No. M35533 CAS No. 1800188-47-9

Vutiglabridin (HSG4112) is a novel and safe modulator of PON2, a racemic compound. vutiglabridin is an optimized structural analogue of Glabridin and is superior to Glabridin in terms of weight loss and chemical stability.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Vutiglabridin
  • Note
    Research use only, not for human use.
  • Brief Description
    Vutiglabridin (HSG4112) is a novel and safe modulator of PON2, a racemic compound. vutiglabridin is an optimized structural analogue of Glabridin and is superior to Glabridin in terms of weight loss and chemical stability.
  • Description
    Vutiglabridin (HSG4112), a racemic compound, is a potent anti-obesity agent. Vutiglabridin, an optimized structural analog of Glabridin, markedly supersedes Glabridin in weight reduction efficacy and chemical stability.
  • In Vitro
    ——
  • In Vivo
    Vutiglabridin (HSG4112) fully reverses adiposity in HFD-induced obese mice in a dose-dependent manner. Vutiglabridin (orally administered with 10, 30, or 100?mg/kg dose for 6 weeks) dose-dependently reduces body weight and normalizes obesity-related parameters in high-fat diet (HFD)-induced obese mice.Animal Model:HFD-induced obese male C57BL/6J mice Dosage:10, 30, and 100?mg/kg Administration:Orally administered for 6 weeks Result:Led to significant dose-dependent body weight reduction by 4.0?g (8.3%), 10?g (21%), and 19?g (40%), respectively, compared to the 48.1?g body weight of HFD-induced obese mice administered with only the vehicle at 10, 30, and 100?mg/kg.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    Phosphatase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1800188-47-9
  • Formula Weight
    354.44
  • Molecular Formula
    C22H26O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (282.14 mM; Ultrasonic )
  • SMILES
    CC1(C)OC2=C(C3=C(CC(CO3)C4=C(O)C=C(OCC)C=C4)C=C2)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. In Yong Bae, et al. Species Differences in Stereoselective Pharmacokinetics of HSG4112, A New Anti-Obesity Agent. Pharmaceutics. 2020 Feb 3;12(2):127.?
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