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KY-226
CAS No. 1621673-53-7
KY-226( —— )
Catalog No. M20927 CAS No. 1621673-53-7
KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM)
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 122 | In Stock |
|
| 5MG | 116 | In Stock |
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| 10MG | 170 | In Stock |
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| 25MG | 282 | In Stock |
|
| 50MG | 431 | In Stock |
|
| 100MG | 690 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameKY-226
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NoteResearch use only, not for human use.
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Brief DescriptionKY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM)
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DescriptionKY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM).
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In VitroWestern Blot Analysis Cell Line:bEnd.3 cells stimulated with LPS Concentration:1 μM Incubation Time:24 hours Result:Rescued lipopolysaccharide-induced reduction of mRNA and protein levels of ZO-1.
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In VivoAnimal Model:Male db/db mice (8-11 weeks old)Dosage:10 mg/kg and 30 mg/kg Administration:Oral administration; daily; for 4 weeks Result:Significantly reduced plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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RecptorPTP1B
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Research Area——
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Indication——
Chemical Information
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CAS Number1621673-53-7
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Formula Weight481.67
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Molecular FormulaC27H31NO3S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (519.03 mM)
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SMILESCCCCCCS(=O)(=O)NC(=O)c1ccc(CSCc2ccc(-c3ccccc3)cc2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ito Y Fukui M Kanda M et al. Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice[J]. Journal of Pharmacological Sciences 2018:S1347861318300422.
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