Tribendimidine

CAS No. 115103-15-6

Tribendimidine( —— )

Catalog No. M35670 CAS No. 115103-15-6

Tribendimidine is a broad-spectrum, orally active anthelmintic and an L-type nicotinic acetylcholine receptor (nAChR) agonist. tribendimidine is highly active against A. lumbricoides and N. americanus.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 46 In Stock
10MG 78 In Stock
25MG 153 In Stock
50MG 229 In Stock
100MG 337 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Tribendimidine
  • Note
    Research use only, not for human use.
  • Brief Description
    Tribendimidine is a broad-spectrum, orally active anthelmintic and an L-type nicotinic acetylcholine receptor (nAChR) agonist. tribendimidine is highly active against A. lumbricoides and N. americanus.
  • Description
    Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist.
  • In Vitro
    Tribendimidine (100 μg/mL; 24 h) shows intoxication of C. elegans.Tribendimidine (0-100 μg/mL; 6 days) shows toxicity with an LC50 value (concentration at which half the animals are dead) of 54.4 μg/mL.Tribendimidine (0-200 μg/mL; 64 h)-induced sterility is resisted by trb mutant hermaphrodites, and Levamisole-resistant mutants are resistant to Tribendimidine.
  • In Vivo
    Tribendimidine (75 and 150 mg/kg; p.o.; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters.Animal Model:C. sinensis infected Female Wistar rats Dosage:75 mg/kg and 150 mg/kg Administration:Oral administration, once Result:A 99.1% worm burden reduction was achieved at 150 mg/kg, and the worm burden reduction was still significant (68.9%) at 75 mg/kg.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    AChR
  • Recptor
    AChR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    115103-15-6
  • Formula Weight
    452.59
  • Molecular Formula
    C28H32N6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (110.48 mM; Ultrasonic; (HCL ,pH≈3); )
  • SMILES
    CN(C)C(\C)=N\c1ccc(cc1)\N=C\c1ccc(\C=N\c2ccc(cc2)\N=C(/C)N(C)C)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xiao SH, et al. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop. 2005 Apr;94(1):1-14.?
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