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Home - Products - GPCR/G Protein - Adenosine Receptor - Trabodenoson

Trabodenoson

CAS No. 871108-05-3

Trabodenoson( —— )

Catalog No. M34723 CAS No. 871108-05-3

Trabodenoson (INO-8875) is a selective and potent adenosine A1 receptor agonist, an adenosine analog, for the study of primary open-angle glaucoma.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Trabodenoson
  • Note
    Research use only, not for human use.
  • Brief Description
    Trabodenoson (INO-8875) is a selective and potent adenosine A1 receptor agonist, an adenosine analog, for the study of primary open-angle glaucoma.
  • Description
    Trabodenoson (INO-8875), an adenosine mimetic, is a highly selective Adenosine A1 receptor agonist. Trabodenoson (INO-8875) is used in the study for Primary Open-Angle Glaucoma.
  • In Vitro
    Trabodenoson treatment significantly increaseS MMP-2 activity and MMP-14 abundance, while decreasing fibronectin and collagen IV expression.
  • In Vivo
    Trabodenoson (6.0%), demonstrating an average IOP drop of 2.45 ± 0.38 mm Hg in young mice over 7 days (downregulation).Topical trabodenoson significantly upregulates nestin expression in the ONH of induced eyes compared with vehicle-treated no-induced eyes.Trabodenoson-treated eyes have significantly reduced optic nerve (ON) edema compared with vehicle-treated eyes. RGC counts are higher in Trabodenoson-treated eyes compared to vehicle (74% versus 47% of the contralateral eye).Animal Model:Young (3-4 months old) and aged (12 months old).Dosage:3% or 6% in 10 μL.Administration:Eye drop for 7 consecutive days.Result:Decreased IOP.Animal Model:Rats.Dosage:3%.Administration:Topical delivery daily.Result:Had significantly reduced optic nerve (ON) edema.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    871108-05-3
  • Formula Weight
    380.36
  • Molecular Formula
    C15H20N6O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (328.64 mM; Ultrasonic )
  • SMILES
    O[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@H]([C@@H]1O)n1cnc2c(NC3CCCC3)ncnc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Guorong Li, et al. Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):383-392.?
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