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Home - Products - GPCR/G Protein - Adenosine Receptor - MRE3008F20

MRE3008F20

CAS No. 252979-43-4

MRE3008F20( —— )

Catalog No. M33435 CAS No. 252979-43-4

MRE3008F20 is a species-selective and potent adenosine A3 receptor (AA3R) antagonist that inhibits Cl-IB-MECA-induced cAMP production and can be used in glaucoma and asthma studies.CAS ??13483-88-88-9

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MRE3008F20
  • Note
    Research use only, not for human use.
  • Brief Description
    MRE3008F20 is a species-selective and potent adenosine A3 receptor (AA3R) antagonist that inhibits Cl-IB-MECA-induced cAMP production and can be used in glaucoma and asthma studies.CAS ??13483-88-88-9
  • Description
    MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM). MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC50 value of 5 nM. MRE3008F20 can be used in the study of AA3R.
  • In Vitro
    MRE3008F20 (0.1-100 nM) antagonizes 100 nM Cl-IB-MECA-induced inhibition of cAMP levels in resting human lymphocytes.Cell Viability Assay Cell Line:Human lymphocytes Concentration:0.1-100 nM Incubation Time: Result:Antagonized 100 nM Cl-IB-MECA-induced inhibition of cAMP levels with an IC50 of 5.0 nM in resting Lymphocytes.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor | cAMP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    252979-43-4
  • Formula Weight
    432.44
  • Molecular Formula
    C21H20N8O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC1=CC=C(OC)C=C1)NC2=NC3=NN(C=C3C4=NC(=NN24)C=5OC=CC5)CCC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gessi S, et al. Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol Pharmacol. 2004 Mar;65(3):711-9.?
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