Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - TRPA1-IN-2

TRPA1-IN-2

CAS No. 2415206-22-1

TRPA1-IN-2( —— )

Catalog No. M36925 CAS No. 2415206-22-1

TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM.TRPA1-IN-2 has anti-inflammatory activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 196 Get Quote
5MG 312 Get Quote
10MG 471 Get Quote
25MG 777 Get Quote
50MG 1086 Get Quote
100MG 1431 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    TRPA1-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM.TRPA1-IN-2 has anti-inflammatory activity.
  • Description
    TRPA1-IN-2 (compound 1) is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM. TRPA1-IN-2 shows anti-inflammation activity.
  • In Vitro
    ——
  • In Vivo
    Animal Model:16-18 g, female BABL/c mice Dosage:90 mg/kg Administration:I.p.; for 7 days Result:Reduced the total number of white blood cells and eosinophils in BALF.Animal Model:160-180 g, SD male rats (asthmatic rats)Dosage:30 mg/kg Administration:I.p.; for 7 days Result:Significantly Sexually reduced lung inflammation area and airway inflammation score in asthmatic rats.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRP/TRPV Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2415206-22-1
  • Formula Weight
    442.48
  • Molecular Formula
    C24H25F3N4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (226.00 mM; Ultrasonic )
  • SMILES
    C(=O)(C1(NC2=CC=C(C#N)C=C2)CCCC1)N3CCN(CC3)C4=CC=C(C(F)(F)F)C=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. YunFeng Cheng, et al. Heteroaromatic acetamide derivative, and preparation and use thereof. WO2020244460A1.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • SB-705498

    A potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor).

  • Pyr6

    Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.Pyr3 is selective inhibitor of TRPC3, inhibited Orai1- and TRPC3-mediated Ca(2+) entry and currents as well as mast cell activation with similar potency.?

  • AMG-0347

    AMG-0347 (UNII-CD7L9290QR) is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in the detection of pain and environmental stimuli. AMG-0347 acts by blocking the function of TRPA1 and has analgesic effects.

Sign In Join Free