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TMS
CAS No. 24144-92-1
TMS( 2,3',4,5'-Tetramethoxystilbene )
Catalog No. M13695 CAS No. 24144-92-1
TMS is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1). It has strong selectivity among P450 family 1 enzymes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 138 | In Stock |
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| 50MG | 251 | In Stock |
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| 100MG | 374 | In Stock |
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| 500MG | 848 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTMS
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NoteResearch use only, not for human use.
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Brief DescriptionTMS is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1). It has strong selectivity among P450 family 1 enzymes.
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DescriptionTMS is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1). It has strong selectivity among P450 family 1 enzymes. TMS exhibits 50-fold selectivity for P450 1B1 over P4501A1 and 500-fold selectivity for P450 1B1 over P450 1A2.
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In VitroTMS, an analogue of resveratrol, is considered to be a potential cancer preventive agent since it is a potent inhibitor of CYP1B1. To assess survival of MCF-7 cells exposed to 1 μM benzo[a]pyrene (BP), 1 μM BP+1 μM TMS and 1 μM BP+4 μM TMS, cells ae incubated for up to 72 h without a media change. Luminescence units from exposed cells, expressed as a percentage of luminescence units from solvent (DMSO)-treated cells at the same time intervals. In all exposure groups, cell viability remains >90% for the first 24 h, but by 72 h, cell survival drops to 60-70%.
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In VivoTo determine the contribution of CYP1B1 in development of hypertension in spontaneously hypertensive rats (SHR), the effect of TMS is examined on in SHR and WKY rats. Systolic BP steadily increases in SHR from 4 weeks of age. Starting from 8 weeks of age, daily injections of TMS reduce systolic BP in SHR to levels observed at the beginning of the experiment (207±7 vs. 129±2 mmHg). Systolic BP is not altered in WKY injected with TMS or its vehicle (129±7 vs. 127±4 mmHg) .
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Synonyms2,3',4,5'-Tetramethoxystilbene
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PathwayMetabolic Enzyme/Protease
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TargetP450
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RecptorCYP450 1B1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number24144-92-1
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Formula Weight300.35
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Molecular FormulaC18H20O4
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESCOC1=CC(OC)=CC(/C=C/C2=CC=C(OC)C=C2OC)=C1
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Chemical Name(E)-1-(3,5-dimethoxystyryl)-2,4-dimethoxybenzene
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Einem Lindeman T,et al. The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzoapyrene-Dna adduct formation in MCF-7 cells exposed to benzoapyrene. Mutagenesis. 2011 Sep;26(5):629-35.
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