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Home - Products - Metabolic Enzyme/Protease - P450 - MS-PPOH

MS-PPOH

CAS No. 206052-02-0

MS-PPOH( —— )

Catalog No. M35273 CAS No. 206052-02-0

MS-PPOH is a potent and selective inhibitor of cytochrome P450 (CYP) epoxygenase, specifically inhibiting CYP2C8 and CYP2C9 with IC50 values of 15 and 11 μM, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    MS-PPOH
  • Note
    Research use only, not for human use.
  • Brief Description
    MS-PPOH is a potent and selective inhibitor of cytochrome P450 (CYP) epoxygenase, specifically inhibiting CYP2C8 and CYP2C9 with IC50 values of 15 and 11 μM, respectively.
  • Description
    MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor. MS-PPOH inhibits CYP2C8 and CYP2C9 with IC50s of 15 and 11 μM, respectively. MS-PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • In Vitro
    MS-PPOH blocks cellular EET synthesis. MS-PPOH inhibits tonic (basal) cell invasion and migration and reduces the 11,12-EET (1.0 μM)-induced cell motility.Cell Viability Assay Cell Line:PC-3 cells Concentration:2.0 and 10.0 μM Incubation Time:24 hours Result:Inhibited tonic (basal) cell invasion and migration.
  • In Vivo
    MS-PPOH (20 mg/kg/day, i.v.) for 6 days significantly reduced renal levels of epoxyeicosatrienoic acids (EETs) in Dahl salt-resistant rats on 2% NaCl drinking solution.Animal Model:Six-week-old male stroke-prone spontaneously hypertensive rats (SHRSP)Dosage:20 mg/kg/day Administration:Intravenously Result:Treatment had negligible effects on systolic blood pressure (SBP) in saline-drinking SHRSP after 1 week, 160 vs. 167 mmHg, or 2 weeks of treatment, 171 vs. 175 mmHg, for vehicle vs. MS-PPOH, respectively.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    P450
  • Recptor
    P450
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    206052-02-0
  • Formula Weight
    323.41
  • Molecular Formula
    C16H21NO4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (618.41 mM; Ultrasonic )
  • SMILES
    C(CCCCC(NS(C)(=O)=O)=O)C1=C(OCC#C)C=CC=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kasem Nithipatikom, et al. Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists. Cancer Sci. 2010 Dec;101(12):2629-36.?
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