TH 5427( TH5427 )

Catalog No. M16929 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TH 5427
Note

Research use only, not for human use.
Brief Description

TH 5427 (TH5427) is a potent, small molecule NUDT5 (NUDIX5) inhibitor with IC50 of 29 nM, 690-fold selectivity for NUDT5 over MTH1 (NUDT1) in vitro.
Description

TH 5427 (TH5427) is a potent, small molecule NUDT5 (NUDIX5) inhibitor with IC50 of 29 nM, 690-fold selectivity for NUDT5 over MTH1 (NUDT1) in vitro; shows little to no effect on NUDT9, dCTPase, NUDT12 and NUDT14; inhibits progestin-dependent nuclear ATP synthesis, subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells; a potent NUDT5 inhibitor that blocks hormone-dependent gene expression in breast cancer cells.
In Vitro

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In Vivo

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Synonyms

TH5427
Pathway

Cell Cycle/DNA Damage
Target

DNA Repair Protein
Recptor

DNA Repair Protein
Research Area

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Indication

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CAS Number

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Formula Weight

491.333
Molecular Formula

C20H20Cl2N8O3
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

7-((5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-1,3-dimethyl-8-(piperazin-1-yl)-3,7-dihydro-1H-purine-2,6-dione

1. Page BDG, et al. Nat Commun. 2018 Jan 17;9(1):250.

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