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Home - Products - Metabolic Enzyme/Protease - Casein Kinase - TBBz

TBBz

CAS No. 577779-57-8

TBBz( Casein Kinase II Inhibitor XII | TBBz )

Catalog No. M15112 CAS No. 577779-57-8

A potent, selective and ATP-competitive CK2 inhibitor with Ki of 0.5-1 uM; weakly inhibits CK1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TBBz
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and ATP-competitive CK2 inhibitor with Ki of 0.5-1 uM; weakly inhibits CK1.
  • Description
    A potent, selective and ATP-competitive CK2 inhibitor with Ki of 0.5-1 uM; weakly inhibits CK1 (about 100-fold less potent), and has no activity for PKA and PKC; decreases the activity of GBM-initiating cell regulator β-catenin, reduces cell growth, decreases tumor size, and increases survival rates in GBM xenograft mouse models.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Casein Kinase II Inhibitor XII | TBBz
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Casein Kinase
  • Recptor
    Casein Kinase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    577779-57-8
  • Formula Weight
    433.72
  • Molecular Formula
    C7H2N2Br4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=NC2=C(N1)C(=C(C(=C2Br)Br)Br)Br
  • Chemical Name
    4,5,6,7-Tetrabromo-1H-benzimidazole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zień P, et al. Biochem Biophys Res Commun. 2003 Jun 20;306(1):129-33. 2. Zien P, et al. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):271-80. 3. Nitta RT, et al. Oncogene. 2015 Jul;34(28):3688-99.
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