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Sivopixant

CAS No. 2414285-40-6

Sivopixant( S-600918 )

Catalog No. M28274 CAS No. 2414285-40-6

Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Sivopixant
  • Note
    Research use only, not for human use.
  • Brief Description
    Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .
  • Description
    Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .(In Vivo):Sivopixant (S-600918) (i.v.;1 mg/kg) shows a longer half-life (T1/2= 10.1 hours) and a strong analgesic effect in the rat Seltzer model of allodynia (ED 50 =0.4 mg/kg) .
  • In Vitro
    ——
  • In Vivo
    Sivopixant (S-600918) (i.v.;1 mg/kg) shows a longer half-life (T1/2= 10.1 hours) and a strong analgesic effect in the rat Seltzer model of allodynia (ED50=0.4 mg/kg).
  • Synonyms
    S-600918
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    P2X Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2414285-40-6
  • Formula Weight
    507.93
  • Molecular Formula
    C25H22ClN5O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@@H](CN(C(N/C(/N1Cc(cc2)ccc2Cl)=N\c(cc2)ccc2Oc2ncccc2)=O)C1=O)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Takahashi T, et al. Absence of cholic acid 7 alpha-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium. J Dairy Sci. 1994 Nov;77(11):3275-86.
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