(E/Z)-Sivopixant

Research use only, not for human use.

(E/Z)-Sivopixantis a potent P2X3 receptor antagonist, IC50 = 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.

(E/Z)-Sivopixantis a potent P2X3 receptor antagonist, IC50 = 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.

ATP receptors are roughly classified into an ion channel type P2X family and a G protein coupled type P2Y family. Seven types of subtypes have been reported in the P2X receptor family, and function as non-selective cation channels by forming homotrimers or heterotrimers with other P2X subtypes. Furthermore, P2X3 that the receptor is expressed in neuroepithelial bodies (NEB) of the lungs, and ATP-induced cough, etc., P2X3 receptors. It has been suggested that it is involved in information transmission in the respiratory organs.

——

(E/Z)-S-600918

Membrane Transporter/Ion Channel

P2X Receptor

hPPARα| human PPARγ

——

——

1640808-39-4

507.93

C25H22ClN5O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (196.88 mM)

C(N1C(NC2=CC=C(OC3=CC=CC=N3)C=C2)=NC(=O)N(C[C@@H](C(O)=O)C)C1=O)C4=CC=C(Cl)C=C4

——

(-20℃)

With Ice Pack

≥ 2 years