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Home - Products - Membrane Transporter/Ion Channel - P2X Receptor - (E/Z)-Sivopixant

(E/Z)-Sivopixant

CAS No. 1640808-39-4

(E/Z)-Sivopixant( (E/Z)-S-600918 )

Catalog No. M28824 CAS No. 1640808-39-4

(E/Z)-Sivopixantis a potent P2X3 receptor antagonist, IC50 = 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 237 In Stock
5MG 212 In Stock
10MG 316 In Stock
25MG 510 In Stock
50MG 681 In Stock
100MG 921 In Stock
200MG Get Quote In Stock
500MG 1832 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    (E/Z)-Sivopixant
  • Note
    Research use only, not for human use.
  • Brief Description
    (E/Z)-Sivopixantis a potent P2X3 receptor antagonist, IC50 = 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.
  • Description
    (E/Z)-Sivopixantis a potent P2X3 receptor antagonist, IC50 = 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.
  • In Vitro
    ATP receptors are roughly classified into an ion channel type P2X family and a G protein coupled type P2Y family. Seven types of subtypes have been reported in the P2X receptor family, and function as non-selective cation channels by forming homotrimers or heterotrimers with other P2X subtypes. Furthermore, P2X3 that the receptor is expressed in neuroepithelial bodies (NEB) of the lungs, and ATP-induced cough, etc., P2X3 receptors. It has been suggested that it is involved in information transmission in the respiratory organs.
  • In Vivo
    ——
  • Synonyms
    (E/Z)-S-600918
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    P2X Receptor
  • Recptor
    hPPARα| human PPARγ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1640808-39-4
  • Formula Weight
    507.93
  • Molecular Formula
    C25H22ClN5O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (196.88 mM)
  • SMILES
    C(N1C(NC2=CC=C(OC3=CC=CC=N3)C=C2)=NC(=O)N(C[C@@H](C(O)=O)C)C1=O)C4=CC=C(Cl)C=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Buse JB, Rubin CJ, Frederich R, et al. Muraglitazar, a dual (alpha/gamma) PPAR activator: a randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with type 2 diabetes. Clin Ther. 2005;27(8):1181-1195.
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