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Home - Products - Membrane Transporter/Ion Channel - iGluR - SYM-2206

SYM-2206

CAS No. 173952-44-8

SYM-2206( SYM2206 )

Catalog No. M12640 CAS No. 173952-44-8

An allosteric, non-competitive antagonist of the AMPA receptor with IC50 of 2.8 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SYM-2206
  • Note
    Research use only, not for human use.
  • Brief Description
    An allosteric, non-competitive antagonist of the AMPA receptor with IC50 of 2.8 uM.
  • Description
    An allosteric, non-competitive antagonist of the AMPA receptor with IC50 of 2.8 uM; acts allosterically at the same regulatory site as GYKI 52466 and 53655 and other benzodiazepines but does not bind to the central diazepine binding site; shows selectivity for AMPA relative to kainate receptor sub-types.Epilepsy Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SYM2206
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    iGluR
  • Research Area
    Neurological Disease
  • Indication
    Epilepsy

Chemical Information

  • CAS Number
    173952-44-8
  • Formula Weight
    366.4137
  • Molecular Formula
    C20H22N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(N1N=C(C2=CC=C(N)C=C2)C3=CC(OCO4)=C4C=C3C1C)NCCC
  • Chemical Name
    1,3-Dioxolo[4,5-g]phthalazine-6(5H)-carboxamide, 8-(4-aminophenyl)-5-methyl-N-propyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pei XF, et al. Bioorg Med Chem Lett. 1999 Feb 22;9(4):539-42. 2. Li P, et al. Nature. 1999 Jan 14;397(6715):161-4. 3. Behr J, et al. Eur J Neurosci. 2002 Sep;16(5):861-7.
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