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Home - Products - Membrane Transporter/Ion Channel - iGluR - NS-1209

NS-1209

CAS No. 245063-59-6

NS-1209( NS1209 | SPD502 )

Catalog No. M13710 CAS No. 245063-59-6

A selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM; display selectivity for the [3H] AMPA over the [3H]kainate- (IC50=81 uM), [3H]CGS19755, and [3H]glycine-binding sites (IC50 > 30 uM) in rat cortical membranes.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    NS-1209
  • Note
    Research use only, not for human use.
  • Brief Description
    A selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM; display selectivity for the [3H] AMPA over the [3H]kainate- (IC50=81 uM), [3H]CGS19755, and [3H]glycine-binding sites (IC50 > 30 uM) in rat cortical membranes.
  • Description
    A selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM; display selectivity for the [3H] AMPA over the [3H]kainate- (IC50=81 uM), [3H]CGS19755, and [3H]glycine-binding sites (IC50 > 30 uM) in rat cortical membranes; inhibits AMPA-induced currents in cortical neurons with IC50 of 0.15 uM; blocks AMPA-evoked spike activity in rat hippocampus (ED50=6.1mg/kg).Stroke Phase 2 Discontinued
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NS1209 | SPD502
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    iGluR
  • Research Area
    Neurological Disease
  • Indication
    Stroke

Chemical Information

  • CAS Number
    245063-59-6
  • Formula Weight
    516.57
  • Molecular Formula
    C24H28N4O7S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)[C@H](O/N=C1C2=C(C(C3)=C(CCN3C)C(C4=CC=C(C=C4)S(N(C)C)(=O)=O)=C2)NC/1=O)CCO
  • Chemical Name
    (R,Z)-2-(((5-(4-(N,N-dimethylsulfamoyl)phenyl)-8-methyl-2-oxo-1,2,6,7,8,9-hexahydro-3H-pyrrolo[3,2-h]isoquinolin-3-ylidene)amino)oxy)-4-hydroxybutanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nielsen EO, et al. J Pharmacol Exp Ther. 1999 Jun;289(3):1492-501. 2. Erichsen HK, et al. Pain. 2002 Jul;98(1-2):151-61. 3. Langer M, et al. Neuropharmacology. 2011 Oct-Nov;61(5-6):1033-47.
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  • NS-1209

    A selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM; display selectivity for the [3H] AMPA over the [3H]kainate- (IC50=81 uM), [3H]CGS19755, and [3H]glycine-binding sites (IC50 > 30 uM) in rat cortical membranes.

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